Computed Tomography Imaging Characteristics of Histologically Confirmed Papillary Renal Cell Carcinoma—Implications for Ancillary Imaging
| Autor: | Jay D. Raman, Alexander Birk, Jeffrey B. Walker, Justin Loloi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
kidney
medicine.medical_specialty Hounsfield Radiography 030232 urology & nephrology Computed tomography lcsh:RC870-923 lcsh:RC254-282 histology 03 medical and health sciences 0302 clinical medicine papillary Renal cell carcinoma Hounsfield scale medicine Tumor imaging Kidney Papillary renal cell carcinomas medicine.diagnostic_test business.industry Histology lcsh:Diseases of the genitourinary system. Urology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease RCC medicine.anatomical_structure Original Article Radiology business 030217 neurology & neurosurgery CT |
| Zdroj: | Journal of Kidney Cancer and VHL Journal of Kidney Cancer and VHL, Vol 6, Iss 2 (2019) |
| ISSN: | 2203-5826 |
| DOI: | 10.15586/jkcvhl.2019.124 |
| Popis: | Low-attenuation renal lesions on non-contrast computed tomography (CT) are often considered to be benign cysts without need for further imaging. However, the papillary subtype of renal cell carcinoma (RCC) may have similar radiographic characteristics. A single-center retrospective review was therefore performed to identify extirpated papillary RCC (pRCC) specimens with correlation made to preoperative tumor imaging characteristics. A total of 108 pRCC specimens were identified of which 84 (27 type I, 17 type 2, 40 unspecified) had CT imaging available for review. Non-contrast CT was available for 73 tumors with 16 (22%) demonstrating Hounsfield units (HU) measurements fewer than 20 at baseline without differences between papillary subtypes. Mean attenuation following contrast administration was similar between papillary subtypes (45 HU for type 1 pRCC and 49 HU for type 2). This study highlights that pathologically proven pRCC is a heterogeneous entity in terms of density on preoperative CT imaging. A non-contrast CT scan with HU fewer than 20 may not be an adequate evaluation for incidental renal masses, as over 1 in 5 pRCCs demonstrate lower attenuation than this cutoff. Further study is needed to identify the appropriate role of ancillary imaging in the workup of seemingly benign-appearing renal lesions. |
| Databáze: | OpenAIRE |
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