Dysphonia induced by anti-angiogenic compounds
Autor: | Erika Saavedra, Jean-Charles Soria, Antoine Hollebecque, Dana M. Hartl |
---|---|
Rok vydání: | 2013 |
Předmět: |
Oncology
Sorafenib medicine.medical_specialty Side effect Bevacizumab Angiogenesis Inhibitors Pharmacology Pazopanib chemistry.chemical_compound Regorafenib Internal medicine otorhinolaryngologic diseases medicine Humans Pharmacology (medical) Aflibercept Clinical Trials as Topic Neovascularization Pathologic Sunitinib business.industry Dysphonia Axitinib chemistry business medicine.drug |
Zdroj: | Investigational New Drugs. 32:774-782 |
ISSN: | 1573-0646 0167-6997 |
Popis: | The number of studies reporting the benefit of angiogenesis inhibition is steadily increasing. Anti-angiogenic drugs, used as monotherapy or in association with chemotherapy, have been shown to benefit patients with several different malignancies. Despite the benefits of these therapies, however, each drug has different side effects. This review is specifically focused on analyzing the frequency of one of the complications the most frequently overlooked by physicians, dysphonia. Perhaps this side effect is overlooked because it is not life-threatening, but dysphonia may nevertheless affect quality of life considerably. We reviewed 88 studies concerning treatment with anti-angiogenics (bevacizumab, aflibercept, sunitinib, sorafenib, pazopanib, axitinib and regorafenib) presently approved for clinical use, to review the incidence of dysphonia or voice changes in phase I, II and III closed clinical studies reported in ClinicalTrials.gov until March 2013. We found that almost all studies reported certain degree of dysphonia in the trial arms associated with anti-angiogenic treatment. We discuss these findings in light of the fact that it is not an uncommon side effect in patients exposed to these kinds of drugs. Particularly for treatments with axitinib, aflibercept and regorafenib, the angiogenesis inhibition possibly plays a role by altering the larynx in some way and modifying vocal fold vibrations, leading to dysphonia. |
Databáze: | OpenAIRE |
Externí odkaz: |