Apoptotic effect as biomarker of disease, severity and follow-up in interstitial cystitis
| Autor: | A. Sanchez-Llopis, J.L. Ruiz-Cerdá, Alicia Martínez-Romero, C. Di Capua-Sacoto, José-Enrique O'Connor |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cystitis Interstitial 030232 urology & nephrology Apoptosis Disease Urine Severity of Illness Index Gastroenterology 03 medical and health sciences 0302 clinical medicine Interstitial cystitis Disease severity Internal medicine Diagnosis Humans Medicine Prospective Studies Prospective cohort study business.industry Pelvic pain Biomarker General Medicine medicine.disease 030220 oncology & carcinogenesis Biomarker (medicine) Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Actas Urologicas Espanolas r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) ACTAS UROLOGICAS ESPANOLAS r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica |
| ISSN: | 2173-5786 0210-4806 |
| DOI: | 10.1016/j.acuroe.2018.03.007 |
| Popis: | Objective: To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis. Material and methods: A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynaecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analysed. A statistical analysis was then conducted to assess whether the apoptotic effect was associated with the symptoms. Results: After performing an analysis of the association between the degree of apoptotic effect and the symptoms of patients with interstitial cystitis, we observed a significant increase in the mean percentages of apoptosis as the degree of symptom severity increased. After analysing the association between the apoptotic effect and symptoms, we obtained a positive correlation in the patients with interstitial cystitis and a lack of correlation in the patients with chronic pelvic pain of gynaecological origin. The rates of apoptosis increased progressively in the patients with interstitial cystitis as the symptoms increased, white the patients with chronic pelvic pain of gynaecological origin remained stable. Conclusions: The apoptotic effect of the urine of patients with interstitial cystitis could be a marker of disease, thus differentiating patients with interstitial cystitis from patients with chronic pelvic pain. The effect could also provide an objective measure of symptom severity. (C) 2017 AEU. Published by Elsevier Espana, S.L.U. All rights reserved. |
| Databáze: | OpenAIRE |
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