Regeneration inducers in limb regeneration

Autor:	Kazumasa Mitogawa, Akira Satoh, Aki Makanae
Rok vydání:	2015
Předmět:	Amphibian animal structures Fibroblast Growth Factor 8 Skin wound Bone Morphogenetic Protein 7 Xenopus Amphibians Axolotl biology.animal Animals Regeneration Organ regeneration Wound Healing biology Regeneration (biology) Extremities Cell Biology Anatomy biology.organism_classification Cell biology Ambystoma mexicanum body regions embryonic structures Fibroblast Growth Factor 2 Blastema Developmental Biology
Zdroj:	Development, Growth & Differentiation. 57:421-429
ISSN:	0012-1592
Popis:	Limb regeneration ability, which can be observed in amphibians, has been investigated as a representative phenomenon of organ regeneration. Recently, an alternative experimental system called the accessory limb model was developed to investigate early regulation of amphibian limb regeneration. The accessory limb model contributed to identification of limb regeneration inducers in urodele amphibians. Furthermore, the accessory limb model may be applied to other species to explore universality of regeneration mechanisms. This review aims to connect the insights recently gained to emboss universality of regeneration mechanisms among species. The defined molecules (BMP7 (or2) + FGF2 + FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9972c47e2432564cb7bffbfc8ea18f8 https://doi.org/10.1111/dgd.12230 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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