Efficacy of maternal and biological parameters at the time of diagnosis of gestational diabetes mellitus in predicting neonatal morbidity
| Autor: | Guillaume Ducarme, François Desroys du Roure, Ingrid Crepin-Delcourt, Aurélie Le Thuaut, Jérôme Dimet, Joséphine Grange |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty endocrine system diseases 030209 endocrinology & metabolism Gestational Age Fetal Macrosomia 03 medical and health sciences Shoulder dystocia Young Adult 0302 clinical medicine Pregnancy Intensive Care Units Neonatal medicine Humans Insulin 030212 general & internal medicine Prospective Studies Glycemic Univariate analysis Obstetrics business.industry Infant Newborn nutritional and metabolic diseases Obstetrics and Gynecology Gestational age medicine.disease Delivery Obstetric Prognosis Dystocia female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Reproductive Medicine Premature Birth Observational study Female medicine.symptom business Weight gain |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 221 |
| ISSN: | 1872-7654 |
| Popis: | Gestational diabetes mellitus (GDM) is independently associated with an increased risk of maternal-fetal complications. Improved glycemic control allows reducing perinatal morbidity and mortality and, specifically, the risk of macrosomia and shoulder dystocia which are the most common complications associated with GDM. Nonetheless, a need for early antenatal predictor of neonatal morbidity in women suffering from GDM is required. The objective of the study was to evaluate the efficacy of different maternal, biological, and antenatal parameters at the time of diagnosis of GDM or perinatal variables as predictors of neonatal morbidity.This was a prospective observational study recruited all pregnant women with diagnosis of GDM at first- or second-trimester in a tertiary care hospital from July 2014 to October 2015. Different antenatal parameters (maternal weight, weight gain during pregnancy, history of GDM, history of macrosomia, serum fructosamine, HbA1c) were obtained at the time of diagnosis of GDM. Mode of delivery was also analyzed. Neonatal morbidity was defined by at least one of the following criteria: preterm birth37 weeks, macrosomia, shoulder dystocia, respiratory distress syndrome, 5-min Apgar score7, pH 7.10 and admission to the NICU (neonatal intensive care unit) for 24 h. Univariate and logistic regression analyses were performed to determine independent antenatal predictors of neonatal morbidity.Two hundred pregnant women with diagnosis of GDM were included. The mean gestational age at the time of diagnosis of GDM was 22 ± 6 weeks. Insulin was required in 72/200 (36%) women for glycemic control during pregnancy. Neonatal morbidity occurred in 21% (n = 42). In the univariate analysis, neonatal morbidity was associated with nulliparity (50% compared to 32%, p = 0.03), induction of labor (36% compared to 27%, p = 0.03) and cesarean section (36% compared to 12%, p 0.01). Multivariable logistic regression analysis found a significant association between nulliparity and neonatal morbidity (adjusted odds ratio [OR] 2.3, 95% confidence interval [CI] 1.1-4.7). Cesarean delivery was also significantly associated with neonatal morbidity (aOR 7.6, 95% CI 2.9-20).This suggests that nulliparity was an efficient antenatal predictor of neonatal morbidity at the time of diagnosis of GDM. Cesarean section was also associated with neonatal morbidity in women with GDM. |
| Databáze: | OpenAIRE |
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