Factors predictive of mortality in a cohort of women surgically treated for breast cancer from 1997 to 2014
| Autor: | Israel Barco, Jose María Lain, Marc García-Font, Antoni Pessarrodona, Ana Carmona, Manel Fraile, Nuria Giménez, Sonia González, Antonio García-Fernández |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lymphovascular invasion medicine.medical_treatment Breast Neoplasms Kaplan-Meier Estimate 030230 surgery Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Humans Mass Screening Prospective Studies Young adult skin and connective tissue diseases Prospective cohort study Survival rate Mass screening Neoadjuvant therapy Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over business.industry Obstetrics and Gynecology General Medicine Middle Aged Prognosis medicine.disease Neoadjuvant Therapy Survival Rate Spain Lymphatic Metastasis 030220 oncology & carcinogenesis Multivariate Analysis Cohort Female Lymph Nodes Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International Journal of Gynecology & Obstetrics. 134:212-216 |
| ISSN: | 0020-7292 |
| Popis: | To determine whether previously reported factors predictive of breast cancer mortality are effectively linked with mortality, particularly breast-cancer-specific mortality.In a prospective study, clinical, surgical, and follow-up data were assessed for consecutive patients with breast cancer who underwent surgery between 1997 and 2014 at two centers in Barcelona, Spain. Predictors of mortality were assessed by multivariate analysis.Overall, 2134 patients were treated for 2206 breast tumors. Overall mortality was 15.0% (n=319), and breast-cancer-specific mortality was 9.0% (n=191). On multivariate analysis, the most significant factors associated with breast-cancer-specific mortality were clinical stage, inmunohistochemical profile, locoregional relapse, and lymphovascular invasion (all P0.001). Age at onset, participation in the mass-screening program, histologic grade, and multicentricity were not significant. Patients with three or more positive axillary nodes sustained a specific mortality significantly higher than did node-negative patients or those with fewer than three positive nodes.Factors predictive of breast cancer mortality were clinical stage, locoregional relapse, molecular classification, lymphovascular invasion, and neoadjuvant chemotherapy. As a single factor, nodal disease becomes relevant only when three or more lymph nodes are involved. |
| Databáze: | OpenAIRE |
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