Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant staphylococcus aureus by interfering with the agr quorum sensing system
| Autor: | Weng C. Chan, Ruth C. Massey, Clarissa Pozzi, Elaine M. Waters, Andrew M. Edwards, Justine K. Rudkin, Eric L. Brown, Maria Gabriela Bowden, Paul Williams, James P. O'Gara |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
T-Lymphocytes
Gene Expression medicine.disease_cause Mice Cell Wall INFECTION Immunology and Allergy Peptide Synthases 11 Medical and Health Sciences 0303 health sciences Cross Infection biology Quorum Sensing 3. Good health COMMUNITY Infectious Diseases Staphylococcus aureus Life Sciences & Biomedicine EXPRESSION Methicillin-Resistant Staphylococcus aureus BACTEREMIA STRAIN Cell Survival Immunology Bacterial Toxins Virulence Microbiology Peptides Cyclic Sepsis 03 medical and health sciences Major Articles and Brief Reports Bacterial Proteins medicine Animals Penicillin-Binding Proteins Secretion 030304 developmental biology PENICILLIN-BINDING PROTEIN-2A Science & Technology Bacteria IDENTIFICATION 030306 microbiology HEMOLYSIN biochemical phenomena metabolism and nutrition 06 Biological Sciences medicine.disease biology.organism_classification bacterial infections and mycoses Methicillin-resistant Staphylococcus aureus Virology GENE EVOLUTION Quorum sensing Cytolysis Disease Models Animal Trans-Activators Methicillin Resistance |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 0022-1899 1537-6613 |
| Popis: | The difficulty in successfully treating infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has led to them being referred to as highly virulent or pathogenic. In our study of one of the major healthcare-associated MRSA (HA-MRSA) clones, we show that expression of the gene responsible for conferring methicillin resistance (mecA) is also directly responsible for reducing the ability of HA-MRSA to secrete cytolytic toxins. We show that resistance to methicillin induces changes in the cell wall, which affects the bacteria's agr quorum sensing system. This leads to reduced toxin expression and, as a consequence, reduced virulence in a murine model of sepsis. This diminished capacity to cause infection may explain the inability of HA-MRSA to move into the community and help us understand the recent emergence of community-associated MRSA (CA-MRSA). CA-MRSA typically express less penicillin-binding protein 2a (encoded by mecA), allowing them to maintain full virulence and succeed in the community environment. © 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. |
| Databáze: | OpenAIRE |
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