Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options
| Autor: | Satoshi Shigematsu, Teiji Takeda, Hidefumi Inaba, Satoru Suzuki, Mitsuhisa Komatsu, Masahiro Takei |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System Thyroid Hormones endocrine system medicine.medical_specialty endocrine system diseases Pituitary Diseases Endocrinology Diabetes and Metabolism Deiodinase Thyroid Gland Thyrotropin Pathogenesis Thyroid hormone receptor beta Endocrinology Antithyroid Agents Thyroid-stimulating hormone Internal medicine medicine Humans Feedback Physiological biology business.industry Thyroid Middle Aged Thyrotoxicosis medicine.anatomical_structure Propylthiouracil Pituitary Gland biology.protein business hormones hormone substitutes and hormone antagonists Endocrine gland medicine.drug Hormone |
| Zdroj: | Endocrine. 40:366-371 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-011-9538-2 |
| Popis: | Thyroid hormone secretion suppresses the expression of thyroid stimulating hormone (TSH), both of which are strictly controlled by a negative feedback loop between the hypothalamus-pituitary and thyroid. Pituitary resistance to thyroid hormone (PRTH) is defined as resistance to the action of thyroid hormone that is more severe in the pituitary than at the peripheral tissue level. Although the molecular basis of PRTH is not well understood, the clinical issue mainly involves imbalance between the hypothalamus-pituitary and peripheral thyroid hormone responsivity, which may induce peripheral thyrotoxic phenomena. Here, we review the pathogenesis and molecular aspects of PRTH, present a single case with inappropriate TSH secretion suffering from thyrotoxicosis treated with PTU, and discuss the possible choice of therapeutic options to correct the imbalance of thyroid hormone responsivity in both the hypothalamus-pituitary and peripheral tissues. |
| Databáze: | OpenAIRE |
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