Exploring thiol-yne based monomers as low cytotoxic building blocks for radical photopolymerization
| Autor: | Andreas Oesterreicher, Petra Kaschnitz, Andreas Moser, Florian Mostegel, Santhosh Ayalur-Karunakaran, Gerald Pinter, Thomas Griesser, Sandra Schlögl, Gregor Trimmel, Matthias Edler |
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| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Biocompatibility Organic Chemistry Ether 02 engineering and technology Dynamic mechanical analysis Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Monomer Photopolymer chemistry Propargyl Materials Chemistry 0210 nano-technology Glass transition |
| Zdroj: | Montanuniversität Leoben |
| Popis: | The last decade has seen a remarkable interest in the development of biocompatible monomers for the realization of patient specific medical devices by means of UV-based additive manufacturing technologies. This contribution deals with the synthesis and investigation of novel thiol-yne based monomers with a focus on their biocompatibility and also the mechanical properties in their cured state. It could be successfully shown that propargyl and but-1-yne-4-yl ether derivatives have a significant lower cytotoxicity than the corresponding (meth)acrylates with similar backbones. Together with appropriate thiol monomers, these compounds show reactivities in the range of (meth)acrylates and almost quantitative triple bond conversions. A particular highlight is the investigation of the network properties of photo cured alkynyl ether/thiol resins by means of low field solid state nuclear magnetic resonance spectroscopy. Additionally, dynamic mechanical analysis of those polymers revealed that monomers containing rigid backbones lead to moduli and glass transition temperatures (Tg's), sufficiently high for the fabrication of medical devices by UV based additive manufacturing methods. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3484–3494 |
| Databáze: | OpenAIRE |
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