Early pregnancy exposure to beta-cypermethrin compromises endometrial decidualisation in mice via downregulation of cyclin D3, CDK4/6, and p21

Autor:	Yong-Jiang, Zhou, Yan-Qing, Geng, Ru-Fei, Gao, Xue-Qing, Liu, Xue-Mei, Chen, Jun-Lin, He
Rok vydání:	2022
Předmět:	Insecticides Estrogen Receptor alpha Down-Regulation General Medicine Toxicology Mice Receptors Estrogen Pregnancy Prenatal Injuries Pyrethrins Decidua Animals Female RNA Messenger Cyclin D3 Receptors Progesterone Food Science
Zdroj:	Food and Chemical Toxicology. 169:113382
ISSN:	0278-6915
Popis:	Beta-cypermethrin (β-CYP) is a highly effective broad-spectrum insecticide that can potentially affect female reproduction. However, little is known about the effect of β-CYP on uterine decidualisation, which is a vital process by which the uterus provides a suitable microenvironment for pregnancy maintenance. Therefore, we focused on the effect and mechanism of β-CYP on endometrial decidualisation during early pregnancy in mice. The results indicated that the expression levels of HOXA10, BMP2, and IGFBP1 was significantly downregulated in the decidual tissue and primary endometrial stromal cells of pregnant and pseudopregnant mice following β-CYP treatment. Serum E
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99024bc99e373993e0fd7a45d635b10 https://doi.org/10.1016/j.fct.2022.113382 Zobrazit plný text záznamu Full Text from ScienceDirect