A Putative Adverse Outcome Pathway Relevant to Carcinogenicity Induced by Sulfuric Acid in Strong Inorganic Acid Mists
| Autor: | Jong-Hyeon Jung, Young Rok Seo, Yeon-Soon Ahn, Nam Kook Kee, Preeyaporn Koedrith, Jun Hyuek Yang, Doo Seok Kang, Cheolmin Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Adverse outcome pathways
0301 basic medicine Future studies Carcinogenesis Chemistry Sulfuric acid Review Sulfuric acids Prolonged exposure 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Increased risk 030220 oncology & carcinogenesis Environmental chemistry Acute exposure Chemical accidents Toxicity Adverse Outcome Pathway otorhinolaryngologic diseases Carcinogen |
| Zdroj: | Journal of Cancer Prevention |
| ISSN: | 2288-3657 2288-3649 |
| DOI: | 10.15430/jcp.2019.24.3.139 |
| Popis: | Based on epidemiological studies, an International Agency for Research on Cancer Working Group determined that strong inorganic acid mists containing sulfuric acid are carcinogenic to human even though, sulfuric acid, per se, is not. Accumulative studies indicate that there is a link between chronic occupational exposure to sulfuric acid mists and an increased risk of laryngeal cancer. Unintended, acute exposure to sulfuric acid mists can cause corrosive damage to target tissues depending on the route of exposure. This review compares the toxicity and carcinogenicity of sulfuric acid mists compared to other strong inorganic acid mists. It also examines the routes and duration of exposure (short-term, prolonged, and long-term). In vivo evidence does not support or refute the carcinogenicity of sulfuric inorganic mists even though its co-carcinogenic or promoting potential has been considered. On the basis of existing evidence on sulfuric acid mist toxicity, we suggested a putative adverse outcome pathway (AOP) relevant to carcinogenicity caused by mists containing sulfuric acid. A possible key factor involved in sulfuric acid mist carcinogenesis is the genotoxic effects of low pH since it can increase instability in chromosomes and DNA. A putative AOP for sulfuric acid mist carcinogenicity would help generate better risk assessments and more accurate predictions regarding the risk of developing cancer due to prolonged exposure. Establishing an AOP would also be useful for future studies examining the carcinogenicity of other strong inorganic mists. |
| Databáze: | OpenAIRE |
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