Engineering silk sericin decorated zeolitic imidazolate framework-8 nanoplatform to enhance chemotherapy
| Autor: | Peng Xue, Jiucun Chen, Yuejun Kang, Cai-E He, Xianbin Ma, Die Jia, Shengxin Hou, Yong-E Gao, Zhigang Xu, Xinyi Li, Yi Lu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biocompatibility
medicine.medical_treatment Nanotechnology 02 engineering and technology 01 natural sciences Sericin chemistry.chemical_compound Colloid and Surface Chemistry Drug Delivery Systems 0103 physical sciences Imidazolate medicine SILK SERICIN Treatment effect Doxorubicin Physical and Theoretical Chemistry Sericins Chemotherapy Drug Carriers 010304 chemical physics Chemistry Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Zeolites 0210 nano-technology Biotechnology Zeolitic imidazolate framework medicine.drug |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 200 |
| ISSN: | 1873-4367 |
| Popis: | The low therapeutic effect and strong side-effect are the major barriers for clinical chemotherapy. Herein, a pH-responsive nanoplatform based-silk sericin-zeolitic imidazolate framework-8 was designed for the delivery of chemotherapeutic doxorubicin (denoted as ZIF-8@DOX@SS, ZDS), which can overcome the limitation of poor circulation stability and unexpected drug leakage in blood circulation, producing a satisfactory chemotherapy. Concretely, ZIF-8 structure shows better stability and biocompatibility owing to the protection of a nature and non-toxic sericin protein. When it comes to low pH environment (e.g. in tumor cell microenvironment), the coordination effect in ZIF-8 will be broken and release DOX drugs. The nano-sized morphology endow ZDS an efficient drug uptake and significant tumor permeability efficiency. Furthermore, the tumor-specific biodegradability makes ZDS possible to realize targeted and enhanced chemotherapy. Considering all the advantages in the study, this silk sericin-based nanosystem represent a promising strategy for the design of stimuli-responsive by using natural polymer to improve the treatment effect of chemotherapy. |
| Databáze: | OpenAIRE |
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