Stimulation of neutrophil chemotaxis, adhesiveness, phagocytosis, and hexose monophosphate shunt activity by N-(2-mercaptopropionyl) glycine
| Autor: | Claudio Rapetto, Franco Patrone, Gianfranco Lanzi, Anna Maria Maggi, Franco Dallegri |
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| Rok vydání: | 1981 |
| Předmět: |
Drug
Neutrophils media_common.quotation_subject Phagocytosis Tiopronin Stimulation General Medicine In Vitro Techniques Pentose phosphate pathway Biology Granulomatous Disease Chronic Defective neutrophil function Stimulation Chemical In vitro Neutrophil chemotaxis Amino Acids Sulfur Chemotaxis Leukocyte Biochemistry Glycine Cell Adhesion Humans Hexosephosphates media_common |
| Zdroj: | Research in Experimental Medicine. 178:257-262 |
| ISSN: | 1433-8580 0300-9130 |
| DOI: | 10.1007/bf01851015 |
| Popis: | The effects of the sulfydryl donor drug N-(2-mercaptopropionyl)-glycine (MPG) on neutrophil chemotaxis, adhesiveness, phagocytosis, and hexose monophosphate shunt activity were investigated in vitro. The drug significantly enhanced all the neutrophil functions tested when used at appropriate concentrations. The results, which are in accord with the well known inhibition of neutrophil function by sulfydryl-blocking agents, suggest the possible therapeutic usefulness of the drug in clinical conditions with defective neutrophil function. |
| Databáze: | OpenAIRE |
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