A panel of autoantibodies as potential early diagnostic serum biomarkers in patients with breast cancer
| Autor: | Siyao Li, Shilong Sun, Kuo Jiang, Linlin Xiang, Ying Liu, Mingmei Huangfu, Ying Liao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Breast Neoplasms Enzyme-Linked Immunosorbent Assay medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer Antigen Antigens Neoplasm Surgical oncology Internal medicine Biomarkers Tumor Humans Medicine Stage (cooking) Early Detection of Cancer Autoantibodies business.industry Autoantibody Hematology General Medicine Middle Aged medicine.disease 030104 developmental biology ROC Curve Case-Control Studies 030220 oncology & carcinogenesis Immunology Biomarker (medicine) Female Surgery business Carcinogenesis |
| Zdroj: | International Journal of Clinical Oncology. 22:291-296 |
| ISSN: | 1437-7772 1341-9625 |
| DOI: | 10.1007/s10147-016-1047-0 |
| Popis: | Specific circulating autoantibodies are produced by host immune systems to respond to antigens that arise during tumorigenesis. To achieve auxiliary diagnosis, the present study was designed to test whether circulating autoantibodies against tumor-associated antigens (TAAs) were altered in early breast cancer. A total of 102 breast cancer patients and 146 age-matched healthy volunteers were recruited to participate in this study. Autoantibody expression was tested using in-house developed enzyme-linked immunosorbent assay (ELISA) with linear peptide envelope antigens derived from TAAs. Student’s t tests showed that expression of autoantibodies against the panel (p16, c-myc, TP53, and ANXA-1) was significantly higher in the breast cancer group, stage I and II breast cancer group, and stage III and IV breast cancer group than in the healthy control group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink