Standardized ethanol-water extract of Ficus deltoidea Angustifolia reduces blood pressure in spontaneously hypertensive rats

Autor:	Nor Hadiani Ismail, Nuraliza Abdul Satar, Mohd Saleh Ahmad Kamal, Norasikin Abdul Azis, Halimatul Saadiah Mohammad Noor, Harbindar Jeet Singh Gurcharan Singh, Zurain Radjeni, Noraini Kasim
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Physiology Urinary system Blood Pressure 030204 cardiovascular system & hematology Antioxidants Losartan Excretion Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Rats Inbred SHR Renin–angiotensin system Heart rate Internal Medicine medicine Animals 030212 general & internal medicine Antihypertensive Agents biology Endothelin-1 Ethanol business.industry Plant Extracts Myocardium Water General Medicine Organ Size biology.organism_classification Ficus Ficus deltoidea Urinary calcium Rats Blood pressure Endocrinology Hypertension Calcium business medicine.drug Phytotherapy
Zdroj:	Clinical and experimental hypertension (New York, N.Y. : 1993). 41(5)
ISSN:	1525-6006
Popis:	Ficus deltoidea is used in Malay traditional medicine for the treatment of a number of disorders, including hypertension. There is, however, no scientific evidence on its anti-hypertensive effects. This study, therefore, investigated the effects of a standardized ethanolic-water extract of Ficus deltoidea Angustifolia (FD-A) on blood pressure (BP) in spontaneously hypertensive rats (SHR). Male SHR with systolic BP of >150 were divided into 4 groups (n = 8) and given either FD-A (800 or 1000 mg kg-1 day-1) or losartan (10 mg kg-1 day-1) or 0.5 ml of distilled water (control) daily for 28 days. BP, body weight, food and water intake, serum and urinary electrolytes, endothelin-1 (ET-1), total antioxidant capacity (TAC) and components of the renin-angiotensin-aldosterone system were measured. Data were analyzed using ANOVA with statistical significance set at p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98e9587715a48b0a652889f26ab4b70 https://pubmed.ncbi.nlm.nih.gov/30648895 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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