The murine Hox-2.4 promoter contains a functional octamer motif
| Autor: | Truus Hoeijmakers, Frits Meijlink, Fried Zwartkruis, Jacqueline Deschamps |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
animal structures
Embryonal Carcinoma Stem Cells Transcription Genetic Recombinant Fusion Proteins Genetic Vectors Molecular Sequence Data CAAT box Biology Mice Transcription (biology) Genetics Animals Histone octamer Hox gene Luciferases Promoter Regions Genetic Transcription factor Regulation of gene expression Expression vector Binding Sites Base Sequence Genes Homeobox Promoter Blotting Northern Molecular biology Gene Expression Regulation embryonic structures Neoplastic Stem Cells Transcription Factors |
| Zdroj: | Nucleic acids research. 20(7) |
| ISSN: | 0305-1048 |
| Popis: | Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenic potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|