Persistent hypoglycemia associated with lipid storage myopathy in a paint foal
| Autor: | Thomas J. Divers, Joe J. Wakshlag, Nikhita P. De Bernardis, Teresa L. Southard, Toby L. Pinn, Stephanie J. Valberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Weakness
medicine.medical_specialty 040301 veterinary sciences Case Report Hypoglycemia 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Endocrinology beta oxidation metabolic Internal medicine biology.animal medicine weakness Myopathy Postmortem Diagnosis General Veterinary biology business.industry Horse 04 agricultural and veterinary sciences medicine.disease horse Foal lipids (amino acids peptides and proteins) medicine.symptom Differential diagnosis EQUID business 030217 neurology & neurosurgery Urine organic acids |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | A 12-hours-old Paint filly was examined because of weakness and dull mentation after birth. Despite IV administered dextrose, the foal remained persistently hypoglycemic with increase in serum activity of muscle and liver enzymes. A postmortem diagnosis of lipid myopathy most similar to multiple acyl-CoA dehydrogenase deficiency (MADD) was confirmed by findings of myofiber lipid accumulation, elevated urine organic acids, and serum free acylcarnitines with respect to control foals. This report details a case of equine neonatal lipid storage myopathy with many biochemical characteristics of MADD. Lipid storage myopathies should be included as a differential diagnosis in foals with persistent weakness and hypoglycemia. |
| Databáze: | OpenAIRE |
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