Ontogenetic study of metaphit-induced audiogenic seizures in rats
Autor: | Slobodan Mirkovic, Veselinka Šušić, Olivera Stanojlović, Dragana Zivanovic |
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Rok vydání: | 2004 |
Předmět: |
Male
medicine.medical_specialty Clonic Convulsion Drug Resistance Phencyclidine Stimulation Convulsants Biology Electroencephalography Inhibitory postsynaptic potential Metaphit Synaptic Transmission Epilepsy Reflex 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Seizures Internal medicine Neural Pathways medicine Reaction Time Animals Genetic Predisposition to Disease Rats Wistar 030304 developmental biology 0303 health sciences medicine.diagnostic_test Age Factors Brain Clonus Rats Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Acoustic Stimulation Animals Newborn Anesthesia Excitatory postsynaptic potential Female Forelimb medicine.symptom 030217 neurology & neurosurgery Developmental Biology |
Zdroj: | Brain research. Developmental brain research. 155(1) |
ISSN: | 0165-3806 |
Popis: | Ontogenetic differences in susceptibility to metaphit (1-(1-(3-isothiocyanatophenyl)cyclohexyl)-piperidine)-induced audiogenic seizures were examined in young, developing (ages: 12, 18, and 25 days) and adult (90 days old) Wistar albino rats. Metaphit was injected in a dose of 10 mg/kg i.p. and animals were subjected to intense audio stimulation (100 ± 3 dB, 60 s) at hourly intervals after administration. Audiogenic seizures (AGS) were scored according to a four point descriptive rating scale (0–3). AGS were elicited in all age groups; they were induced for 12, 15, 15, and 30 h in 12-, 18-, 25-day-old, and adult rats, respectively. Younger animals reached a peak incidence and severity of seizures before adult rats. Twenty-five-day-old rats showed greatest incidence and severity of seizures, and shortest latency. Twelve-day-old animals had longest latencies. Besides audiogenic seizures, we observed convulsions induced by metaphit only in the form of running episodes, forelimb clonus, clonic convulsions, and rearing. Results suggest that young rats develop metaphit-induced sound seizures more rapidly, but that adults have longer period of seizure susceptibility. Different susceptibility to seizures is probably due to changes in excitatory and inhibitory pathways, while maturation of blood–brain barrier is less probable, since metaphit has a lipophilic nature. |
Databáze: | OpenAIRE |
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