Simultaneous Directed Assembly of Three Distinct Heterodimeric Coiled Coils

Autor:	Alan J. Kennan, Maria L. Diss
Rok vydání:	2008
Předmět:	Models Molecular Crystallography Chemistry Stereochemistry Molecular Sequence Data Organic Chemistry Urea Amino Acid Sequence Physical and Theoretical Chemistry Peptides Biochemistry Protein Structure Secondary
Zdroj:	Organic Letters. 10:3797-3800
ISSN:	1523-7052 1523-7060
Popis:	We describe simultaneous formation of three distinct heterodimeric coiled coils from a mixture of six different peptides. The choice among electrostatically viable complexes is governed by alignment of buried core residues, including a fundamentally new interaction that exploits urea-terminated side chains. Buried urea/urea contacts lead to extremely stable dimeric coiled coils, with T(m) values between 63 and 79 degrees C. Core ureas can also form stable complexes with a variety of other polar groups, including guanidines, acids, and amides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98aa7214420efd08e8ed90fe684f44d https://doi.org/10.1021/ol801461a Zobrazit plný text záznamu