Simultaneous Directed Assembly of Three Distinct Heterodimeric Coiled Coils
Autor: | Alan J. Kennan, Maria L. Diss |
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Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Organic Letters. 10:3797-3800 |
ISSN: | 1523-7052 1523-7060 |
Popis: | We describe simultaneous formation of three distinct heterodimeric coiled coils from a mixture of six different peptides. The choice among electrostatically viable complexes is governed by alignment of buried core residues, including a fundamentally new interaction that exploits urea-terminated side chains. Buried urea/urea contacts lead to extremely stable dimeric coiled coils, with T(m) values between 63 and 79 degrees C. Core ureas can also form stable complexes with a variety of other polar groups, including guanidines, acids, and amides. |
Databáze: | OpenAIRE |
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