Retinal nerve fibre layer thickness changes in Alzheimer's disease: Results from a 12-month prospective case series
| Autor: | Magda Gharbiya, Fabrizia D'Antonio, Alessandro Trebbastoni, Letizia Imbriano, Alessandra Campanelli, Michela Cecere, Alice Bruscolini, Michela Marcelli, Carlo de Lena |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty retinal nerve fibre layer thickness Nerve fibre layer Neuropsychological Tests Retina alzheimer’s disease biomarker optical coherence tomography 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Alzheimer Disease Ophthalmology medicine Humans Vision test Prospective Studies Cognitive decline Prospective cohort study Aged Aged 80 and over Series (stratigraphy) business.industry General Neuroscience Vision Tests Retinal Optic Nerve Middle Aged Control subjects Surgery chemistry 030221 ophthalmology & optometry Optic nerve Female business 030217 neurology & neurosurgery Biomarkers Tomography Optical Coherence |
| Zdroj: | Neuroscience letters. 629 |
| ISSN: | 1872-7972 |
| Popis: | Purpose To compare the 12-month peripapillary retinal nerve fibre layer (pRNFL) thickness change between AD patients and normal subjects. Methods In this prospective case series, thirty-six patients with a diagnosis of mild to moderate AD and 36 age-matched control subjects were included. All the subjects underwent neuropsychological (MMSE, ADAS-Cog and CDR) and ophthalmological evaluation, including spectral domain optical coherence tomography (SD-OCT), at baseline and after 12 months. Results Compared with controls, AD patients had a significant reduction of the total pRNFL thickness, as well as the pRNFL thickness of the inferior and superior quadrants (p = 0.04, p = 0.001, and p = 0.01, respectively, adjusted for baseline pRNFL measurement, age, gender, and axial length). Correlation analysis showed a significant relationship between inferior pRNFL thickness change and ADAS-Cog scores change (r = −0.35, p = 0.02) as well as CDR scores at 12 months (r = −0.39, p = 0.008). Conclusions Compared with controls, AD patients had a significant reduction in pRNFL thickness over a period of 12 months. The pRNFL reduction was more prominent in the inferior quadrant and paralleled patient’s cognitive decline. |
| Databáze: | OpenAIRE |
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