Oral solution of levodopa ethylester for treatment of response fluctuations in patients with advanced Parkinson's disease
| Autor: | Silvia Honigman, Ruth Djaldetti, Yehudit Peretz-Aharon, Nir Giladi, Yuval Herishano, Eldad Melamed, Sami Badarny, Rivkah Inzelberg, Martin Rabey, Amos D. Korczyn |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Levodopa Parkinson's disease Administration Oral Biological Availability Antiparkinson Agents Route of administration Pharmacokinetics Double-Blind Method Oral administration medicine Humans Morning Aged Neurologic Examination Gastric emptying business.industry digestive oral and skin physiology Carbidopa Middle Aged medicine.disease Drug Combinations Treatment Outcome Neurology Anesthesia Female Neurology (clinical) business medicine.drug |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 17(2) |
| ISSN: | 0885-3185 |
| Popis: | Levodopa ethylester (LDEE), a highly soluble prodrug of levodopa, may overcome the impaired absorption of regular levodopa, due mainly to a combination of levodopa's poor solubility and delayed gastric emptying. We conducted a double-blind, levodopa-controlled, multicenter study of oral LDEE solution compared with standard levodopa-carbidopa (LD-CD) tablets. Sixty-two patients with Parkinson's disease who had "delayed on" and "no-on" subtypes of response fluctuations were randomly assigned for treatment with LDEE-CD or LD-CD 250/25 mg for 4 weeks (phase A). Only the first morning and first post-lunch dose of LD were replaced. This was followed by a 2-week extension with a supplementation of carbidopa (25 mg) to each replaced dose (phase B). Patients filled home diaries 2 weeks before and during the trial period in which times of turning on and off for the two doses were reported. In phase A, mean latency to turning on was reduced by 21% (morning dose) and 17% (post-lunch dose) in the LDEE-CD group. Percentage of no-on episodes after the post-lunch dose was decreased by 21% in the LDEE-CD group but increased by 36% in the LD-CD group (P < 0.01). In phase B, LDEE-CD decreased latencies to on after the morning and post-lunch doses and no-on episodes after the post-lunch dose. The beneficial effects of LDEE were supported by the pharmacokinetic data. Results indicate that LDEE solution is beneficial in ameliorating delayed on and no-on response fluctuations. This effect of LDEE is due to more rapid levodopa absorption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text