Effects of Hexachloro-1,3-Butadiene and 1,1,2,2-Tetrachloroethylene on Individual Serum Bile Acids
| Autor: | Paul J. Canfield, Neill H. Stacey, Cheng-Long Bai |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Tetrachloroethylene medicine.medical_specialty Bilirubin Health Toxicology and Mutagenesis Toxicology Serum enzymes Bile Acids and Salts chemistry.chemical_compound Liver Function Tests Occupational Exposure Internal medicine Butadienes polycyclic compounds medicine High doses Animals Liver injury medicine.diagnostic_test Public Health Environmental and Occupational Health 1 3-Butadiene Rats Inbred Strains medicine.disease Fungicides Industrial Rats Hexachlorobutadiene Endocrinology chemistry Biochemistry Liver function tests |
| Zdroj: | Toxicology and Industrial Health. 8:191-203 |
| ISSN: | 1477-0393 0748-2337 |
| Popis: | Rats were exposed to hexachlorobutadiene (HCBD) or tetrachloroethylene (TET) in order to determine which of these chemicals was more likely to be responsible for elevations in individual serum bile acids (SBA) found in workers exposed primarily to these two chemicals. Increases in cholic and taurocholic acids were found on exposure to high doses of HCBD. Elevations of SBA occurred right down to low exposures for TET, however, with cholic, chenodeoxycholic, and glycocholic acids being the most sensitive bile acids. Only at high doses for each chemical was there any indication of liver injury as determined by routinely used parameters such as serum enzymes or bilirubin. The data suggest that TET is likely to play a role in the elevated individual SBA in an exposure situation where both this chemical and HCBD are found. |
| Databáze: | OpenAIRE |
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