Characterisation of mouse monoclonal antibodies produced by immunisation with a single serotype component of a polyvalent Pseudomonas aeruginosa vaccine
| Autor: | Elizabeth A. Roe, D.B.L. McClelland, Keith James, P. L. Yap, M C McCann, L.R. Micklem, G. R. Barclay, Roderick John Jones |
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| Rok vydání: | 1986 |
| Předmět: |
Microbiology (medical)
Serotype medicine.drug_class Biology Monoclonal antibody medicine.disease_cause Microbiology Mice Antigen Antibody Specificity Cell Wall medicine Animals Serotyping Polyvalent Vaccine Pseudomonas aeruginosa Antibodies Monoclonal General Medicine biology.organism_classification Antibodies Bacterial Virology Bacterial vaccine Bacterial Vaccines biology.protein Antibody Pseudomonadaceae |
| Zdroj: | Journal of Medical Microbiology. 21:87-90 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/00222615-21-1-87 |
| Popis: | Mouse monoclonal antibodies raised by immunisation with a protective antigen extract from Pseudomonas aeruginosa serotype 1 varied in immunoglobulin isotype, in passive protective properties against infection by homologous P. aeruginosa serotype 1, and in cross-reactions in ELISA against antigen preparations from 15 other P. aeruginosa serotypes. All monoclonal antibodies with specificity in ELISA for the immunising antigen gave some degree of protection to mice against lethal infection by the homologous P. aeruginosa serotype. The IgG antibodies were more protective than the IgM antibodies. |
| Databáze: | OpenAIRE |
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