Comparative study on age-dependent development of surface receptors on peripheral blood lymphocytes in children and young nonhuman primates (marmosets)
| Autor: | Sabine Gerstmayr, Isabella Delgado, Klaus Abraham, Michael H. Foerster, Reinhard Neubert |
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| Rok vydání: | 1997 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adolescent CD2 Antigens CD11a CD8-Positive T-Lymphocytes General Biochemistry Genetics and Molecular Biology Flow cytometry Antigens CD Reference Values medicine Animals Humans Lymphocyte Count General Pharmacology Toxicology and Pharmaceutics Child Receptor CD20 B-Lymphocytes biology medicine.diagnostic_test CD11 Antigens Cell adhesion molecule Integrin beta1 Infant Callithrix CD29 General Medicine Antigens CD20 biology.organism_classification CD56 Antigen Lymphocyte Subsets Animals Newborn Child Preschool Immunology biology.protein Leukocyte Common Antigens CD8 |
| Zdroj: | Life Sciences. 60:773-785 |
| ISSN: | 0024-3205 |
| Popis: | General conformity was found concerning age-dependent changes in the major subsets (CD4, CD8, CD2, CD20) and the adhesion molecules CD11a and CD29 on peripheral blood lymphocytes in children and young marmosets (Callithrix jacchus). Differences exist in the expression of the surface receptors CD45RA and CD56. Taking the total number of white blood cells into account, an age-related increase in the absolute numbers of peripheral blood lymphocytes was found in marmosets whereas in children, an age-dependent decrease was observed. The definition of reference ranges for different stages of maturation in children and young marmosets may serve as a basis on which comparative risk assessment of possible effects on lymphocyte subsets after pre- or perinatal drug exposure can be estimated. |
| Databáze: | OpenAIRE |
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