Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in mice
| Autor: | Thomas M. Gray, F. J. Murray, Linda G. Roberts, Ceinwen A. Schreiner, Rochelle W. Tyl, Charles R. Clark, Gary M. Hoffman, Melissa C. Marr, GW Trimmer |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Methyl tertiary butyl ether (MTBE) Developmental toxicity Ether Alcohol Toxicology Risk Assessment Fetal Development Mice chemistry.chemical_compound Animal science Toxicity Tests Animals Diisopropyl ether Ectopia cordis Oxygenate Gastroschisis Air Pollutants Ethanol Weight change Gasoline vapor condensates Fetal Body Weight General Medicine Inhalation chemistry Fuel oxygenates Evaporative emissions Female Gasoline |
| Zdroj: | Regulatory Toxicology and Pharmacology. 70:S58-S68 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2014.06.011 |
| Popis: | Gasoline-vapor condensate (BGVC) or condensed vapors from gasoline blended with methyl t-butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME) diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were evaluated for developmental toxicity in Sprague-Dawley rats exposed via inhalation on gestation days (GD) 5-20 for 6h/day at levels of 0 (control filtered air), 2000, 10,000, and 20,000mg/m(3). These exposure durations and levels substantially exceed typical consumer exposure during refueling ( |
| Databáze: | OpenAIRE |
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