Clinical, virological and epidemiological characterization of an outbreak of Testudinid Herpesvirus 3 in a chelonian captive breeding facility: Lessons learned and first evidence of TeHV3 vertical transmission
| Autor: | Patrizia Casagrande Proietti, Valentina Stefanetti, Carmen Maresca, Lorenzo Santoni, Monica Sforna, Maria Pia Franciosini, Andrea Felici, Francesco C. Origgi, Maria Luisa Marenzoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epidemiology Viral pathogenesis lcsh:Medicine Testudinid herpesvirus Artificial Gene Amplification and Extension Disease Breeding Pathology and Laboratory Medicine Testudo hermanni Polymerase Chain Reaction Scutavirus Testudinid herpesvirus neurological disease Testudo hermanni temperature-effect Serology Animal Diseases 0403 veterinary science Database and Informatics Methods Medicine and Health Sciences neurological disease lcsh:Science Herpesviridae Multidisciplinary 630 Agriculture Transmission (medicine) Eukaryota 04 agricultural and veterinary sciences Herpesviridae Infections Turtles Tortoises Medical Microbiology Viral Pathogens Vertebrates Viruses Pathogens Sequence Analysis Research Article medicine.medical_specialty Herpesviruses Viral Release 040301 veterinary sciences Bioinformatics Biology Research and Analysis Methods Microbiology Virus 03 medical and health sciences Virology medicine Animals Viral shedding Molecular Biology Techniques Molecular Biology Microbial Pathogens DNA sequence analysis Scutavirus lcsh:R Organisms Outbreak Biology and Life Sciences Reptiles temperature-effect Infectious Disease Transmission Vertical 030104 developmental biology Testudines Amniotes 570 Life sciences biology lcsh:Q DNA viruses Sequence Alignment Viral Transmission and Infection |
| Zdroj: | PLoS ONE Marenzoni, Maria Luisa; Santoni, Lorenzo; Felici, Andrea; Maresca, Carmen; Stefanetti, Valentina; Sforna, Monica; Franciosini, Maria Pia; Casagrande Proietti, Patrizia; Origgi, Francesco (2018). Clinical, virological and epidemiological characterization of an outbreak of Testudinid Herpesvirus 3 in a chelonian captive breeding facility: Lessons learned and first evidence of TeHV3 vertical transmission. PLoS ONE, 13(5), e0197169. Public Library of Science 10.1371/journal.pone.0197169 PLoS ONE, Vol 13, Iss 5, p e0197169 (2018) |
| DOI: | 10.7892/boris.129625 |
| Popis: | Testudinid herpesviruses (TeHVs) have a worldwide distribution among tortoises. However, information such as risk factors promoting the occurrence or the recrudescence of the associated disease and the mid-term sequelae of an outbreak comprising the extent and dynamic of the viral shedding have been only minimally investigated. Critical management information is also lacking or anecdotal. Furthermore, major aspects of the viral pathogenesis including the likelihood of vertical transmission of the virus are virtually unknown. The present study describes the occurrence and the management of an outbreak of Testudinid herpesvirus genotype 3 (TeHV3) in a large, private collection of chelonians. Clinical, pathological, molecular and serological characterization of the outbreak were carried out. Seventy-five percent of the infected tortoises died. Complementation of molecular and serological testing was a critical point for successful management implementations. A case-control study was performed to analyze possible risk factors associated with the infection. Furthermore, a subgroup of six asymptomatic infected tortoises was monitored for two consecutive seasons after the outbreak: all the infected tortoises were determined to be intermittent shedders, except one, which was a persistent shedder. Post-hibernation was associated with the highest number of shedders. Finally, evidence of the most likely vertical transmission of the virus was obtained for the first time. |
| Databáze: | OpenAIRE |
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