Parkinson's disease and microRNAs - Lessons from model organisms and human studies
| Autor: | Howard A. Furlong, Brian Evans, Alexandre de Lencastre |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Parkinson's disease ved/biology.organism_classification_rank.species Disease Biology Biochemistry Article Pathogenesis Endocrinology microRNA Genetics medicine Humans Model organism Molecular Biology ved/biology Dopaminergic Neurons Neurodegeneration Dopaminergic Cancer Neurodegenerative Diseases Parkinson Disease Cell Biology medicine.disease MicroRNAs Neuroscience |
| Zdroj: | Exp Gerontol |
| ISSN: | 0531-5565 |
| Popis: | Parkinson’s disease (PD) is a progressive, age-associated neurodegenerative disorder that affects an estimated 10 million people worldwide. PD is characterized by proteinaceous, cytoplasmic inclusions containing α-synuclein, called Lewy Bodies, which form in dopaminergic neurons in an age-dependent manner, and are associated with the emergence of characteristic PD symptoms such as resting tremor, rigidity, slow movements and postural instability. Although considerable progress has been made in recent years in identifying genetic and environmental factors that are associated with PD, early diagnosis and therapeutic options remain severely lacking. Recently, microRNAs (miRNAs) have emerged as novel therapeutic targets in various diseases, such as cancer and neurodegenerative diseases. MiRNAs have been shown to play roles in various aging and neurodegenerative disease models across phyla. More recently, studies have identified specific roles for miRNAs and their targets in the pathogenesis and progression of PD in several model organisms. Here, we discuss the evolving field of miRNAs, their association with PD, and the outlook for the future. |
| Databáze: | OpenAIRE |
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