Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
| Autor: | Cédric Auffray, Naishitha Anaparthy, Douglas T. Fearon, Z. Larkin Kelley, Mikala Egeblad, Arnaud Pommier, Ran Yan, Nicoletta Memos, Christine A. Iacobuzio-Donahue, Alizee Gouronnec, Scott K. Lyons, Jean Albrengues |
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| Rok vydání: | 2018 |
| Předmět: |
X-Box Binding Protein 1
0301 basic medicine XBP1 T-Lymphocytes Genes MHC Class I Protein Serine-Threonine Kinases Major histocompatibility complex Lymphocyte Depletion Metastasis Mice 03 medical and health sciences Immune system Pancreatic cancer Endoribonucleases MHC class I medicine Animals Humans Keratin-19 Multidisciplinary biology Endoplasmic reticulum Liver Neoplasms Neoplasms Experimental Endoplasmic Reticulum Stress medicine.disease Mice Inbred C57BL Pancreatic Neoplasms 030104 developmental biology Cancer research biology.protein Unfolded protein response Tumor Escape Genetic Engineering Carcinoma Pancreatic Ductal |
| Zdroj: | Science. 360 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Chronic stress as a survival tactic Most patients with pancreatic ductal adenocarcinoma (PDA) develop liver metastases after surgical removal of their primary tumor. These metastases are thought to potentially arise from quiescent disseminated cancer cells, likely present at the time of surgery, which evade elimination by the immune system. Pommier et al. explored how these quiescent cells survive by analyzing mouse models and tissue samples from patients with PDA. They found that disseminated cancer cells do not express a cell surface molecule that triggers killing by T cells. This phenotypic feature is linked to their inability to resolve endoplasmic reticulum stress. When this stress is resolved, the disseminated cells begin proliferating and form metastases. Science , this issue p. eaao4908 |
| Databáze: | OpenAIRE |
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