Morphologically 'invisible' proinsulin - secreting adenoma detected by Ga-68 Exendin-4 (GLP-1 Receptor) positron emission tomography/CT
| Autor: | Christoph Werner, Ulrich Müller, Masoud Mireskandari, Astrid Bauschke, Robert Drescher, Martin Freesmeyer, Christian Stoykow, Amelie Lupp |
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| Rok vydání: | 2017 |
| Předmět: |
Adenoma
Adult Male endocrine system Pathology medicine.medical_specialty 030209 endocrinology & metabolism Gallium Radioisotopes Malignancy Glucagon-Like Peptide-1 Receptor 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Pancreatic lesion Receptor Insulinoma Glucagon-like peptide 1 receptor Proinsulin medicine.diagnostic_test business.industry medicine.disease Pancreatic Neoplasms Oncology Positron emission tomography 030220 oncology & carcinogenesis business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of medical imaging and radiation oncology. 62(3) |
| ISSN: | 1754-9485 |
| Popis: | This case report of a young man suffering from recurring hypoglycaemia illustrates a rare condition of a neuroendocrine tumour, predominantly secreting proinsulin and invisible to conventional imaging approaches. Only a GLP-1 receptor PET/CT using Exendin-4 visualized the pancreatic lesion and enabled curative therapy, confirming the diagnostic value of this tracer for detection of neuroendocrine tumours. As only few publications on this topic are available, an overview of the available data is also given. The known cut-off value of 60% for proinsulin level indicating malignancy is critically discussed. |
| Databáze: | OpenAIRE |
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