Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer
| Autor: | Ru-Tian Hao, Hai-Guang Liu, Li Wan, Xiu-Ling Wu, You-Qun Xiang, Yi-fei Pan, Xiao-Hua Zhang |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
CA15-3 Adult Cancer Research medicine.medical_specialty Pathology Breast Neoplasms Metastasis Breast cancer Recurrence Internal medicine medicine Humans Neoplasm Invasiveness RNA Messenger Lymph node Survival analysis Aged Proportional hazards model business.industry Reverse Transcriptase Polymerase Chain Reaction Cancer General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis Neoplasm Proteins medicine.anatomical_structure Lymphatic Metastasis Female Breast disease Protein Tyrosine Phosphatases business |
| Zdroj: | Journal of cancer research and clinical oncology. 136(9) |
| ISSN: | 1432-1335 |
| Popis: | The aim of this study was to investigate the expression of the PRL-3 in human invasive breast cancer and to evaluate its clinical and prognostic significance. Its potential role in the invasive-metastatic properties of invasive breast cancer was also investigated. Protein expression of PRL-3 was evaluated by immunohistochemistry for a consecutive series of 82 invasive human breast cancer tissues and 63 matched lymph node metastases, including PRL-3 mRNA expression analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) in malignant, nonmalignant breast tissue samples and lymph node metastases. We investigated the correlation of PRL-3 with clinicopathologic features, Overall and recurrence-free survival distribution curves were assessed using the Kaplan–Meier test and log-rank statistics, followed by Cox proportional hazards regression model. We found that 70.7% patients expressed a high level of PRL-3 protein in their tumors, and its over expression was positive correlated with lymph node metastasis (LNM) (P = 0.011). Moreover, The PRL-3 mRNA expression was significantly higher in malignant compared to benign breast tissue, while increased expression of PRL-3 mRNA was significantly associated with LNM (P = 0.002). Univariate analysis showed that the positive expression of PRL-3 was a poor risk prognostic factor (OS, P = 0.045; RFS, P = 0.034). Multivariate analysis using the Cox regression model indicated that high PRL-3 expression was an independent unfavorable prognostic factor for RFS. These results strongly suggest that PRL-3 expression can indicate the potential role of LNM to some extent. Increasing the risk of tumor metastasis (OR = 3.889). Our results also imply that PRL-3 might be a novel molecular marker for predicting relapse of invasive breast cancer. |
| Databáze: | OpenAIRE |
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