JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
| Autor: | Marie Anne Breau, Christel Moog-Lutz, Florence C. Guibal, Pierre G. Lutz, Sandrine Bourdoulous, Florence Cavé-Riant, Yolande Di Gioia, Yvon E. Cayre, Pierre-Olivier Couraud |
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| Přispěvatelé: | Neurosignalisation Moleculaire et Cellulaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2003 |
| Předmět: |
Acute promyelocytic leukemia
Junctional Adhesion Molecules [SDV]Life Sciences [q-bio] Cellular differentiation Molecular Sequence Data Immunology Retinoic acid Tretinoin Biology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Cell Adhesion Leukocytes Tumor Cells Cultured medicine Humans RNA Messenger Cell adhesion 030304 developmental biology 0303 health sciences Base Sequence Cell adhesion molecule Myeloid leukemia Cell Differentiation Cell Biology Hematology medicine.disease Cell biology Gene Expression Regulation chemistry Leukemia Myeloid 030220 oncology & carcinogenesis Immunoglobulin superfamily Endothelium Vascular Cell Adhesion Molecules Sequence Analysis medicine.drug |
| Zdroj: | Blood Blood, American Society of Hematology, 2003, 102 (9), pp.3371-3378. ⟨10.1182/blood-2002-11-3462⟩ Blood, 2003, 102 (9), pp.3371-3378. ⟨10.1182/blood-2002-11-3462⟩ |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2002-11-3462 |
| Popis: | Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid–induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule–like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration. |
| Databáze: | OpenAIRE |
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