Hepato-renal toxicity of oral sub-chronic exposure to aluminum oxide and/or zinc oxide nanoparticles in rats
| Autor: | Maher A. Kamel, Thulfiqar Fawwaz Mutar, Mokhtar Ibrahim Yousef |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
GSH
reduced glutathione ALT alanine transaminase Health Toxicology and Mutagenesis chemistry.chemical_element DNA fragmentation Zinc GPX glutathione peroxidase 010501 environmental sciences Pharmacology Toxicology Systemic inflammation medicine.disease_cause 01 natural sciences Article GST glutathione S-transferase PGC-1α peroxisome proliferator activator receptor gamma-coactivator 1α 03 medical and health sciences 0302 clinical medicine ROS reactive oxygen species lcsh:RA1190-1270 AST aspartate transaminase SOD superoxide dismutase AlP alkaline phosphatase medicine GGT gamma-glutamyl transferase Fragmentation (cell biology) Receptor lcsh:Toxicology. Poisons 0105 earth and related environmental sciences ComputingMethodologies_COMPUTERGRAPHICS Aluminum oxide nanoparticles LDH lactate dehydrogenase Chemistry TFAM TBARS thiobarbituric acid-reactive substances mtTFA mitochondrial transcription factor A Oxidative stress Toxicity ACP acid phosphatase Zinc oxide nanoparticles Gene expression medicine.symptom CAT catalase Cytokines and p53 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 6, Iss, Pp 336-346 (2019) |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Oral sub-chronic exposure to Aluminum oxide or zinc oxide nanoparticles has hepato-renal toxicity. • The toxicities of Aluminum oxide and/or zinc oxide NPs mediated through different correlated pathways. • The pathways including; epigenetic changes, impaired antioxidant systems, induced oxidative stress and disturbed cytokine production. • Exaggerated hepatic and renal toxicities of combined exposure to both NPs. Aluminum oxide nanoparticles (Al2O3NPs) and zinc oxide nanoparticles (ZnONPs) have been involved in many industries and they are extensively abundant in many aspects of human life. Consequently, concerns have been raised about their potentially harmful effects. However the toxicities of Al2O3NPs and ZnONPs are well documented, the effect of co-exposure to both nanoparticles remains strictly obscure. Therefore, the present study was undertaken to address this issue. Four groups of male Wistar rats (10 rats each) were used; control, Al2O3NPs treated, ZnONPs treated and Co-treated groups. Rats were orally administered their respective treatment daily for 75 days. The effects of each nanoparticle alone or in combination were assessed at different levels including; hepatic and renal function, structure, and redox status, nuclear DNA fragmentation, hepatic expression of mitochondrial transcription factor A (mtTFA) gene and peroxisome proliferator-activated receptor gamma-coactivator 1α (PGC-1α), systemic inflammation, and hematologic parameters. The results confirmed the hepatorenal toxicities of each nanoparticle used at the level of all parameters with suppression of the hepatic expression of mtTFA and PGC-1α. The co-exposure to both nanoparticles results in synergistic effects. From these results, we can conclude that co-exposure to aluminum oxide nanoparticles and zinc oxide nanoparticles results in more pronounced hepatorenal toxicities and systemic inflammation. |
| Databáze: | OpenAIRE |
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