Potential role of regulatory B cells in immunological diseases
| Autor: | Amir Valizadeh, Gholamreza Azizi, Roozbeh Sanaei, Saba Fekrvand, Asghar Aghamohammadi, Nima Rezaei, Reza Yazdani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Allergy Regulatory B cells medicine.medical_treatment Immunology Disease medicine.disease_cause Autoimmunity 03 medical and health sciences Mice 0302 clinical medicine Immune system Neoplasms medicine Immunology and Allergy Animals Humans Chronic infectious disease B-Lymphocytes Regulatory business.industry biochemical phenomena metabolism and nutrition medicine.disease Phenotype 030104 developmental biology Cytokine Immune System Diseases bacteria business 030215 immunology |
| Zdroj: | Immunology letters. 215 |
| ISSN: | 1879-0542 |
| Popis: | Regulatory B cells (Bregs) are immune-modulating cells that affect the immune system by producing cytokines or cellular interactions. These cells have immunomodulatory effects on the immune system by cytokine production. The abnormalities in Bregs could be involved in various disorders such as autoimmunity, chronic infectious disease, malignancies, allergies, and primary immunodeficiencies are immune-related scenarios. Ongoing investigation could disclose the biology and the exact phenotype of these cells and also the assigned mechanisms of action of each subset, as a result, potential therapeutic strategies for treating immune-related anomalies. In this review, we collect the findings of human and mouse Bregs and the therapeutic efforts to change the pathogenicity of these cells in diverse disease. |
| Databáze: | OpenAIRE |
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