HOUT-23. ASSOCIATION BETWEEN TREATMENT FACILITY VOLUME AND MORTALITY IN PATIENTS WITH GLIOBLASTOMA (GBM): A LARGE NATIONAL ANALYSIS
| Autor: | Sonikpreet Aulakh, Steven S. Rosenfeld, Sikander Ailawadhi, Asher Chanan-Khan, Michelle DeDeo, Alfredo Quinones-Hinojosa, Kyle Berdeguez, Joseph Free |
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| Rok vydání: | 2018 |
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| Zdroj: | Neuro-Oncology. 20:vi118-vi118 |
| ISSN: | 1523-5866 1522-8517 |
| Popis: | BACKGROUND: GBM is an aggressive and incurable primary malignancy of the brain, treated with surgical resection and chemo-radiotherapy, yet it has a dismal prognosis of 12–14 month overall survival (OS). Optimal outcomes require an experienced team providing multidisciplinary management. We explored the association of treatment facility volume and mortality in patients with GBM. METHODS: We identified incident GBM (ICD-O-3 code: 9440/3) cases from the National Cancer Database (NCDB) (2004–2013) and utilized Cox-regression to determine the facility volume-outcome (volume=quartiles; Q) relationship, adjusting for year of diagnosis, demographic (sex, age, race, ethnicity), socio-economic (income, education, insurance type), geographic (area of residence, treatment facility location, travel distance) and co-morbidity factors (Charlson-Deyo score). RESULTS: There were 114,467 patients (median age 60 years, range: 18–90) with GBM treated at 1207 facilities of which, 54.8% were men. Median annual facility volume was 5 patients/year (range: 0.1–136.4). The top 14 (1.2%) facilities treated >60 patients/year (10%). Median overall survival (OS) was 15 months There were significant differences (all p |
| Databáze: | OpenAIRE |
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