The loss of expression of transforming growth factor-β receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients
| Autor: | Issac Y. Kim, Byung Ha Chung, Sung Joon Hong, Hideo Tokunaga, Seung Choul Yang, Dong Hyeon Lee, Seth P. Lerner, Ronald A. Morton, Hyun Jik Chung, Yun S Song |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Carcinoma Transitional Cell Pathology medicine.medical_specialty Growth factor medicine.medical_treatment General Medicine Tumor initiation Middle Aged Biology urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Urinary Bladder Neoplasms Reference Values TGF beta signaling pathway Carcinoma medicine Humans Immunohistochemistry Receptor Beta (finance) Receptors Transforming Growth Factor beta Aged Transforming growth factor |
| Zdroj: | Yonsei Medical Journal. 40:118 |
| ISSN: | 0513-5796 |
| DOI: | 10.3349/ymj.1999.40.2.118 |
| Popis: | Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-beta through a loss of expression of TGF-beta receptors T beta R-I and T beta R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-beta receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T beta R-I and T beta R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-beta receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T beta R-I and T beta R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-beta receptors. However, among grade II TCC samples, T beta R-I and T beta R-II were detected in 78% and 89%, respectively: among grade III TCC samples, T beta R-I and T beta R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-beta may play a role in the progression of TCC from low to high grade disease. |
| Databáze: | OpenAIRE |
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