PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements
| Autor: | Bo-jie Li, Caiping Zhang, Qin-Hui Tuo, Hao Chen, Duan-Fang Liao, Chu-yao Wang, Su-su Jiang, Shiyin Long |
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| Rok vydání: | 2019 |
| Předmět: |
Physiology
Endosome 030310 physiology Biophysics Intracellular Space Kinesins Microtubules 03 medical and health sciences Structure-Activity Relationship Microtubule Animals Humans Protein Interaction Domains and Motifs 030304 developmental biology 0303 health sciences Chemistry Vesicle Cell Membrane Cell Biology PX domain Membrane transport Cell biology Protein Transport Kinesin Rab Disease Susceptibility Carrier Proteins Intracellular Protein Binding |
| Zdroj: | The Journal of membrane biology. 253(2) |
| ISSN: | 1432-1424 |
| Popis: | As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport of intracellular cargo and the formation of endosomal tubules. Ras-related protein (Rab) coordinates many steps of membrane transport and are involved in the regulation of KIF16B-mediated vesicle trafficking. Data obtained from clinical research suggest that KIF16B has a potential effect on the disease processes in intellectual disability, abnormal lipid metabolism, and tumor brain metastasis. In this review, we summarize recent advances in the structural and physiological characteristics of KIF16B as well as diseases associated with KIF16B disorders, and speculating its role as a potential adaptor for intracellular cholesterol trafficking. |
| Databáze: | OpenAIRE |
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