Two Formulations of the Agricultural Pesticide Adjuvant, Toximul™, Reduce the Glycogen Content of HepG2 Cells
| Autor: | Patrick A. O'Regan, Mary G. Murphy, Laurette Geldenhuys, Philip D. Acott, Mustafa Al-Khalidi, Jacqueline Upham, John F. S. Crocker |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Hepatic glycogen Chemistry Pharmaceutical Health Toxicology and Mutagenesis medicine.medical_treatment Agricultural pesticides Biology Toxicology Mice Surface-Active Agents chemistry.chemical_compound fluids and secretions Internal medicine medicine Animals Viability assay Organic Chemicals Pesticides Cells Cultured Glycogen Pesticide Endocrinology Liver Biochemistry chemistry Hepg2 cells Toxicity bacteria Adjuvant |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 70:1772-1775 |
| ISSN: | 1087-2620 1528-7394 |
| DOI: | 10.1080/10937400601171340 |
| Popis: | Young mice exposed dermally to the Toximul (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 +/- 3 microg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells. |
| Databáze: | OpenAIRE |
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