Report of severe accidental baclofen intoxication in a healthy 4-year-old boy and review of the literature
| Autor: | S. le Bot, Xavier Declèves, C. de Marcellus, Sylvain Renolleau, Mehdi Oualha, F. Baud |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Baclofen medicine.medical_treatment Ventricular system Drug overdose Severity of Illness Index Cerebral edema 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics medicine Humans Coma Mechanical ventilation Pediatric intensive care unit business.industry musculoskeletal neural and ocular physiology medicine.disease nervous system chemistry Anesthesia Accidental Child Preschool Pediatrics Perinatology and Child Health medicine.symptom Drug Overdose business |
| Zdroj: | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 26(8) |
| ISSN: | 1769-664X |
| Popis: | The number of reports on baclofen intoxication has increased in recent years. Here we report the case of a 4-year-old boy in deep coma who was referred to the pediatric intensive care unit. The patient was intubated and mechanically ventilated. A computerized tomography scan without contrast showed a collapsed appearance of the ventricular system suggesting diffuse cerebral edema. A multichannel electroencephalogram registered 6 h after admission showed a very slow and ample continuous pattern, without structure, nonreactive to stimulations, expressing diffuse and severe nonspecific cerebral pain. A targeted analysis to determine the baclofen plasma levels was performed. Test results of plasma samples were highly positive for baclofen (2009 ng/mL). Following 36 h of mechanical ventilation, the patient rapidly regained consciousness and recovered normal neurological behavior. The present case demonstrates the importance of considering baclofen overdosage in cases of deep coma with areflexia, and emphasizes the importance of warning parents about the potential toxicity of baclofen when prescribing the drug to a family member. A review of the literature on pediatric baclofen overdose is included. |
| Databáze: | OpenAIRE |
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