Bronchocele density in cystic fibrosis as an indicator of allergic broncho-pulmonary aspergillosis: A preliminary study
| Autor: | Béatrice Leloutre, Carole Bailly, Caroline Ranc, Aurélie Occelli, Sébastien Soize, Lisa Giovannini-Chami, Corinne Boyer, Marie Baque-Juston |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Cystic Fibrosis Aspergillosis Cystic fibrosis 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Hounsfield scale Medicine Humans Radiology Nuclear Medicine and imaging Child Retrospective Studies Observer Variation Bronchocele business.industry Aspergillosis Allergic Bronchopulmonary General Medicine medicine.disease Mucus Bronchiectasis 030228 respiratory system Child Preschool Broncho-pulmonary Female Radiology business Complication Tomography X-Ray Computed Pediatric population |
| Zdroj: | European journal of radiology. 93 |
| ISSN: | 1872-7727 |
| Popis: | Objective Allergic broncho-pulmonary aspergillosis (ABPA) is a severe and under-diagnosed complication of cystic fibrosis (CF). The aim of the study was to determine whether the mucus content of bronchoceles in cystic fibrosis complicated with ABPA reveals a higher density than the mucus content of non-ABPA cystic fibrosis. Materials and methods We studied retrospectively 43 computed tomography scans (CT scans) of a pediatric population of cystic fibrosis patients. We measured the mucus attenuation in Hounsfield Units (HU) of all bronchoceles >5 mm in diameter. Results We found bronchoceles >5 mm in 13/43 patients. 5/13 patients had a positive diagnosis of ABPA. The median HU value of bronchoceles was higher in patients with than without ABPA [98 HU (26–135) vs 28 HU (10–36); P = 0,02]. Moreover, all patients with a bronchocele density >36HU were ABPA positive. Conclusions CF complicated with ABPA shows higher attenuation bronchoceles on CT scans of the chest. Systematic density measurements of bronchoceles could help to raise the difficult diagnosis of ABPA in patients suffering from cystic fibrosis. Larger series could confirm a threshold in HU which could become a new imaging criterion for the diagnosis of ABPA. |
| Databáze: | OpenAIRE |
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