Enhanced Susceptibility to Subcutaneous Abscess Formation and Persistent Infection around Catheters Is Associated with Sustained Interleukin-1β Levels
| Autor: | Jean-Luc Murk, T. van der Poll, Jan J. Weening, S.A.J. Zaat, Jacob Dankert, Jaap Jan Boelens |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Micrococcaceae Immunology Biocompatible Materials Staphylococcal infections Microbiology Mice Catheters Indwelling Staphylococcus epidermidis medicine Animals Subcutaneous abscess Abscess Host Response and Inflammation biology Interleukin Staphylococcal Infections biology.organism_classification medicine.disease Mice Inbred C57BL Catheter Infectious Diseases Female Parasitology Disease Susceptibility Complication Interleukin-1 |
| Zdroj: | Infection and immunity, 68(3), 1692-1695. American Society for Microbiology |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | A persistentStaphylococcus epidermidisinfection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1β (IL-1β) production was found. Apparently, sustained levels of IL-1β are associated with enhanced susceptibility to biomaterial-associatedS. epidermidisinfection. |
| Databáze: | OpenAIRE |
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