Medical male circumcision and HIV prevention among men in Kwazulu-Natal, South Africa: A propensity score analysis
| Autor: | Lara Lewis, Lateef O. Amusa, Temesgen Zewotir, Ayesha B. M. Kharsany, Delia North |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Matching (statistics) Multidisciplinary Propensity score business.industry Confounding Human immunodeficiency virus (HIV) HIV Odds ratio medicine.disease_cause Medical male circumcision Kwazulu-Natal South Africa Male circumcision Epidemiology Propensity score matching medicine lcsh:Q lcsh:Science business Kwazulu natal Demography |
| Zdroj: | Scientific African, Vol 11, Iss, Pp e00683-(2021) |
| ISSN: | 2468-2276 |
| DOI: | 10.1016/j.sciaf.2020.e00683 |
| Popis: | Introduction Epidemiological theory and many empirical studies support the hypothesis that there is a protective effect of medical male circumcision (MMC) against HIV infection. We aim to test this claim with evidence from a high endemic community in South Africa. Methodology We analysed a cross-sectional dataset, including HIV test outcome and MMC status of males aged 15–49, who participated in the HIV Incidence Provincial Surveillance System study between June 2014 and June 2015. We applied two propensity score methods, inverse probability of treatment weighting (IPTW) and full matching, to approximate a randomised trial investigating the hypothesis that MMC protects against HIV infection. We benchmarked our results using the conventional regression adjustment. Models were adjusted for identified confounders. Results The adjusted odds ratios (OR) provided evidence of a protective effect of MMC against HIV acquisition: IPTW (OR = 0.623, 95% CI: 0.467 – 0.830); Full matching (OR = 0.607, 95% CI: 0.440 – 0.837); Regression (OR = 0.579, 95% CI: 0.426 – 0.789). Conclusion There is a need to create more programmes that emphasise MMC as an important HIV preventive intervention. |
| Databáze: | OpenAIRE |
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