Fatal Fulminant Hepatitis Associated with Bromfenac Use
| Autor: | Megan J Smith, Peter Stenzel, John M. Rabkin, Susan L. Orloff, Christopher L. Corless, Ali J. Olyaei |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Pain 030204 cardiovascular system & hematology Liver transplantation Chronic liver disease 030226 pharmacology & pharmacy Gastroenterology Benzophenones 03 medical and health sciences Fatal Outcome 0302 clinical medicine Fulminant hepatic failure Internal medicine medicine Humans Pharmacology (medical) Decompensation Fulminant hepatitis Hepatic encephalopathy medicine.diagnostic_test business.industry Arthritis Anti-Inflammatory Agents Non-Steroidal Middle Aged medicine.disease Surgery Liver Hepatic Encephalopathy Female Bromfenac Liver function tests business Bromobenzenes medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 33:945-947 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1345/aph.18364 |
| Popis: | OBJECTIVE: To report a case of fulminant hepatic failure associated with the use of bromfenac, a new analog of the phenyl acetate class of nonsteroidal antiinflammatory drugs. CASE SUMMARY: A 60-year-old white woman with liver failure who had no known history of chronic liver disease was transferred to the liver transplant unit for evaluation. For three months preceding her illness, the patient was treated with bromfenac 25 mg po qid for arthritic pain. Prior to the initiation of bromfenac, her liver function test results were normal. Etiologic evaluation at presentation was unremarkable. The patient's condition continued to deteriorate, with the development of hepatic encephalopathy and worsening liver function test results while awaiting liver transplantation. Progressive hepatic and renal dysfunction along with respiratory decompensation ensued, and the patient died 48 days after initial presentation. CONCLUSIONS: Fulminant hepatic failure associated with the prolonged use of bromfenac appears to be an idiosyncratic response consistent with experience with other agents of its class. This case along with other cases of serious hepatotoxicity associated with the use of this agent ultimately resulted in bromfenac's removal from the market. |
| Databáze: | OpenAIRE |
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