Patient-Reported Disease-Modifying Therapy Adherence in the Clinic: A Reliable Metric?
| Autor: | Devon S. Conway, Robert J. Fox, Kaila N Parker, Maria Cecilia Vieira, Xiangyi Meng, Nicolas R. Thompson |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Lesion formation Patient reporting Therapy adherence Disease Logistic regression Original Research Paper Multiple sclerosis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine Neurology (clinical) Metric (unit) disease-modifying therapies business 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis Journal-Experimental, Translational and Clinical |
| ISSN: | 2055-2173 |
| DOI: | 10.1177/2055217318777894 |
| Popis: | Background Adherence to multiple sclerosis (MS) disease-modifying therapy (DMT) is commonly assessed through patient reporting, but patient-reported adherence is rarely studied. Objective To determine rates of DMT adherence reported from patient to clinician, reasons for nonadherence, and relationships between adherence and outcomes. Methods We identified relapsing–remitting MS patients on DMT for ≥3 months. DMT adherence was defined as taking ≥80% of doses. Linear and logistic regression models were created used to determine the association of baseline adherence with several patient reported outcomes and the timed 25-foot walk at 6 months, 1 year, 2 years, and 3 years after the index visit. Results The analysis included 1148 patients, of whom 501 had data at 6 months, 544 at 1 year, 331 at 2 years, and 247 at 3 years. Baseline adherence was 94.9% and overall adherence was 93.1%. Forgetting was the most common reason for missed doses. In the adjusted models, adherence was not associated with the outcomes. Conclusions Higher than expected adherence and a lack of association between adherence and outcomes suggests patient reported adherence may not be reliable. Further research is needed to clarify the relationship between patient-reported adherence and relapses or new lesion formation. |
| Databáze: | OpenAIRE |
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