Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma

Autor: Chitra Subramanian, Mark S. Cohen, Anna Schwendeman, Peter T. White, James J. Moon, Rui Kuai, Barbara N. Timmermann
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_treatment
Pharmaceutical Science
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Drug Delivery Systems
International Journal of Nanomedicine
Drug Discovery
Adrenocortical Carcinoma
Adrenocortical carcinoma
Cytotoxicity
Original Research
Chemistry
targeted delivery
scavenger receptor class B1
General Medicine
Scavenger Receptors
Class B

3. Good health
Cholesterol
030220 oncology & carcinogenesis
synthetic high-density lipoproteins
Lipoproteins
HDL

adrenocortical carcinomas
Half-Life
medicine.medical_specialty
Biophysics
Phospholipid
Mice
Nude

Bioengineering
Antineoplastic Agents
Biomaterials
03 medical and health sciences
In vivo
Internal medicine
Cell Line
Tumor

medicine
Animals
Humans
Particle Size
IC50
Withanolides
Apolipoprotein A-I
withalongolides
Organic Chemistry
Biological Transport
medicine.disease
Xenograft Model Antitumor Assays
nanodisks
Adrenal Cortex Neoplasms
Nanostructures
Steroid hormone
030104 developmental biology
Endocrinology
Peptides
Zdroj: International Journal of Nanomedicine
ISSN: 1178-2013
1176-9114
Popis: Rui Kuai,1,2,* Chitra Subramanian,3,* Peter T White,3,* Barbara N Timmermann,4 James J Moon,1,2,5 Mark S Cohen,3,6 Anna Schwendeman1,2 1Department of Pharmaceutical Sciences, College of Pharmacy, 2Biointerfaces Institute, University of Michigan, 3Department of Surgery, University of Michigan, Ann Arbor, MI, 4Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, 5Department of Biomedical Engineering, 6Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA *These authors contributed equally to this work Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival rate of
Databáze: OpenAIRE