Latrophilin-3 disruption: Effects on brain and behavior
| Autor: | Charles V. Vorhees, Samantha L. Regan, Michael T. Williams |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Subfamily
Receptors Peptide Cognitive Neuroscience Central nervous system Regulator Brain Cognition Biology medicine.disease Article Receptors G-Protein-Coupled Behavioral Neuroscience Neuropsychology and Physiological Psychology medicine.anatomical_structure Attention Deficit Disorder with Hyperactivity Neuroplasticity medicine Latrophilin 3 Attention deficit hyperactivity disorder Animals Humans Receptor Neuroscience |
| Zdroj: | Neurosci Biobehav Rev |
| Popis: | Latrophilin-3 (LPHN3), a G-protein-coupled receptor belonging to the adhesion subfamily, is a regulator of synaptic function and maintenance in brain regions that mediate locomotor activity, attention, and memory for location and path. Variants of LPHN3 are associated with increased risk for attention deficit hyperactivity disorder (ADHD) in some patients. Here we review the role of LPHN3 in the central nervous system (CNS). We describe synaptic localization of LPHN3, its trans-synaptic binding partners, links to neurodevelopmental disorders, animal models of Lphn3 disruption in different species, and evidence that LPHN3 is involved in cognition as well as activity and attention. The evidence shows that LPHN3 plays a more significant role in neuroplasticity than previously appreciated. |
| Databáze: | OpenAIRE |
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