Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al2O3-nanoparticle
| Autor: | Dayong Wang, Qi Rui, Shunhui Yu, Ting Cai, Yinxia Li, Qiuli Wu |
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| Rok vydání: | 2011 |
| Předmět: |
Chronic exposure
Pathology medicine.medical_specialty Health Toxicology and Mutagenesis Metal Nanoparticles Biology Toxicology medicine.disease_cause Fluorescence Lipofuscin Oxidative damage Fight-or-flight response Aluminum Oxide medicine Animals Intestinal Mucosa Caenorhabditis elegans Pharmacology chemistry.chemical_classification Reactive oxygen species General Medicine Molecular biology Intestines Oxidative Stress Autofluorescence chemistry Acute exposure Reactive Oxygen Species Oxidative stress |
| Zdroj: | Environmental Toxicology and Pharmacology. 32:233-241 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2011.05.008 |
| Popis: | In nematodes, acute exposure (24-h) to 8.1-30.6 mg/L Al(2)O(3)-nanoparticles (NPs) or Al(2)O(3) did not influence intestinal autofluorescence, whereas chronic exposure (10-d) to Al(2)O(3)-NPs at concentrations of 8.1-30.6 mg/L or Al(2)O(3) at concentrations of 23.1-30.6 mg/L induced significant increases of intestinal lipofuscin accumulation, and formation of severe stress response and oxidative damage in intestines. Moreover, significant differences of intestinal autofluorescence, stress response and oxidative damage in intestines of Al(2)O(3)-NPs exposed nematodes from those in Al(2)O(3) exposed nematodes were detected at examined concentrations. Oxidative damage in intestine was significantly correlated with intestinal autofluorescence in exposed nematodes, and oxidative damage in intestine was more closely associated with intestinal autofluorescence in nematodes exposed to Al(2)O(3)-NPs than exposed to Al(2)O(3). Thus, chronic exposure to Al(2)O(3)-NPs may cause adverse effects on intestinal lipofuscin accumulation by inducing the formation of more severe oxidative stress in intestines than exposure to Al(2)O(3) in nematodes. |
| Databáze: | OpenAIRE |
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