Virological Outcomes of EVG/COBI/FTC/TDF and EVG/COBI/FTC/TAF in Antiretroviral-Naive HIV-1-Infected Participants with Baseline HIV-1 RNA ≥1,000,000 Copies/ml: A Post Hoc Analysis of Phase III Clinical Trials
| Autor: | Kirsten L. White, Damian J McColl, Edwin DeJesus, Christian Callebaut, David Piontkowsky, Hui Wang, Martin S. Rhee, Paul E. Sax, Jennifer Demorin, Erin Quirk, Moupali Das, David A. Wohl, Calvin J. Cohen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Oncology medicine.medical_specialty business.industry Human immunodeficiency virus (HIV) Phases of clinical research medicine.disease_cause 030112 virology Antiretroviral therapy Hiv 1 rna Clinical trial 03 medical and health sciences Infectious Diseases Internal medicine Post-hoc analysis medicine Antiretroviral naive Pharmacology (medical) business Viral load |
| Zdroj: | Antiviral Therapy. 23:95-99 |
| ISSN: | 2040-2058 1359-6535 |
| DOI: | 10.3851/imp3187 |
| Popis: | We address a data gap identified by Adams et al., of virological efficacy outcomes and emergent drug resistance in HIV-1-infected, antiretroviral treatment (ART)-naive participants with baseline (BL) viral loads (VL) >1,000,000 copies/ml. Initial ART regimens including an integrase strand transfer inhibitor (INSTI) cause a rapid decline in VL. In two cases described, the VL response on the single tablet regimen (STR) of co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate (EVG/COBI/FTC/TDF) was |
| Databáze: | OpenAIRE |
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