Temporal summation of trigeminal pain in human anterior cingulate cortex
| Autor: | Holger Kaube, Hans-Christoph Diener, Armin de Greiff, Mark Obermann, P. Stude, Burkhard Pleger, Zaza Katsarava |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pain Threshold Cognitive Neuroscience Pain Summation Gyrus Cinguli Brain mapping Young Adult Image Interpretation Computer-Assisted Threshold of pain medicine Humans Trigeminal Nerve Evoked Potentials Anterior cingulate cortex Skin Trigeminal nerve Brain Mapping medicine.diagnostic_test Chronic pain Brain medicine.disease Magnetic Resonance Imaging Electric Stimulation medicine.anatomical_structure Nociception Neurology Face Female Functional magnetic resonance imaging Psychology Neuroscience |
| Zdroj: | NeuroImage. 46:193-200 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2009.01.038 |
| Popis: | Temporal summation of nociceptive inputs in trigeminal networks can induce central sensitization and maintain chronic pain. We combined functional magnetic resonance imaging and electrically evoked pain-related potentials (PREP) in healthy human subjects to identify brain regions involved in temporal summation of nociceptive inputs. We stimulated the skin innervated by the ophthalmic division of the trigeminal nerve with trains of three, seven and eleven similar nociceptive pulses, while recording evoked hemodynamic or electrical brain responses. We found that PREP amplitudes and pain ratings increased in parallel with increasing train length. Strikingly, only hemodynamic responses in the posterior part of the anterior cingulate cortex (pACC) scaled with individual pain ratings on a verbal rating scale (VRS) and electrically evoked responses (i.e., PREP amplitudes for the three train lengths). These findings indicate that pACC codes temporal summation of trigeminal nociception and in this regard may be important for the development of central sensitization observed in chronic head and facial pain. |
| Databáze: | OpenAIRE |
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