Umbilical cord as an analytical matrix – A technical note
| Autor: | Stuart J. Knight, Alexander D. Smith, Michael W.H. Coughtrie, Abby C. Collier, Dickson Lai, Tricia E. Wright, Hugh Kim, Hayley R. Price, Camron Chehroudi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Analyte Computer science Drug Evaluation Preclinical Umbilical cord Mass Spectrometry Umbilical Cord Matrix (chemical analysis) 03 medical and health sciences 0302 clinical medicine Placenta medicine Humans Laboratory methods 030219 obstetrics & reproductive medicine Obstetrics and Gynecology Technical note Small sample Fetal Blood 3. Good health 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Blood supply Developmental Biology Biomedical engineering |
| Zdroj: | Placenta. 90:42-44 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2019.12.001 |
| Popis: | The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount available, ease of collection, small sample needed for use, rapid availability) and challenges (clinical relationships, processing difficulties, matrix effects on analytes and detection technologies) of UC as an analytical matrix in ELISA and LC/MS platforms, and provides guidance for successfully working with this tissue. |
| Databáze: | OpenAIRE |
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