A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
| Autor: | Yuan-Jun Song, Yan-Hong Wang, Jiehui Jing, Zhen Hu, Yudong Huang, Chunhua Zhang, Xiang-Li Meng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Nitration
Hydrochloride Pharmaceutical Science Salt (chemistry) Aminopyridines High-performance liquid chromatography Nitric Acid Intermediate product Article Analytical Chemistry lcsh:QD241-441 Synthesis chemistry.chemical_compound lcsh:Organic chemistry Nitric acid Drug Discovery Organic chemistry 6-Tetraaminopyridine Physical and Theoretical Chemistry 3 5 Hydrogenation chemistry.chemical_classification Molecular Structure Organic Chemistry Oleum chemistry Chemistry (miscellaneous) Yield (chemistry) Molecular Medicine Salts 2 3 5 6-Tetraaminopyridine |
| Zdroj: | Molecules Molecules; Volume 14; Issue 5; Pages: 1652-1659 Molecules, Vol 14, Iss 5, Pp 1652-1659 (2009) |
| ISSN: | 1420-3049 |
| Popis: | A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP x 3HCl x H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis. |
| Databáze: | OpenAIRE |
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